The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants.
Identifieur interne : 000205 ( PubMed/Checkpoint ); précédent : 000204; suivant : 000206The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants.
Auteurs : Kristian W. Pajtler [Allemagne] ; Stephen C. Mack [États-Unis] ; Vijay Ramaswamy [Canada] ; Christian A. Smith [Canada] ; Hendrik Witt [Allemagne] ; Amy Smith [États-Unis] ; Jordan R. Hansford [Australie] ; Katja Von Hoff [Allemagne] ; Karen D. Wright [États-Unis] ; Eugene Hwang [États-Unis] ; Didier Frappaz [France] ; Yonehiro Kanemura [Japon] ; Maura Massimino [Italie] ; Cécile Faure-Conter [France] ; Piergiorgio Modena [Italie] ; Uri Tabori [Canada] ; Katherine E. Warren [États-Unis] ; Eric C. Holland [États-Unis] ; Koichi Ichimura [Japon] ; Felice Giangaspero [Italie] ; David Castel [France] ; Andreas Von Deimling [Allemagne] ; Marcel Kool [Allemagne] ; Peter B. Dirks [Canada] ; Richard G. Grundy [Royaume-Uni] ; Nicholas K. Foreman [États-Unis] ; Amar Gajjar [États-Unis] ; Andrey Korshunov [Allemagne] ; Jonathan Finlay [États-Unis] ; Richard J. Gilbertson [Royaume-Uni] ; David W. Ellison [États-Unis] ; Kenneth D. Aldape [Canada] ; Thomas E. Merchant [États-Unis] ; Eric Bouffet [Canada] ; Stefan M. Pfister [Allemagne] ; Michael D. Taylor [Canada]Source :
- Acta neuropathologica [ 1432-0533 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Consensus, Humains, Prise en charge de la maladie, Stade de la tumeur, Tumeurs du cerveau (), Tumeurs du cerveau (anatomopathologie), Tumeurs du cerveau (génétique), Tumeurs du cerveau (métabolisme), Épendymome (), Épendymome (anatomopathologie), Épendymome (génétique), Épendymome (métabolisme).
- MESH :
- anatomopathologie : Tumeurs du cerveau, Épendymome.
- génétique : Tumeurs du cerveau, Épendymome.
- métabolisme : Tumeurs du cerveau, Épendymome.
- Animaux, Consensus, Humains, Prise en charge de la maladie, Stade de la tumeur, Tumeurs du cerveau, Épendymome.
English descriptors
- KwdEn :
- MESH :
- genetics : Brain Neoplasms, Ependymoma.
- metabolism : Brain Neoplasms, Ependymoma.
- pathology : Brain Neoplasms, Ependymoma.
- therapy : Brain Neoplasms, Ependymoma.
- Animals, Consensus, Disease Management, Humans, Neoplasm Staging.
Abstract
Multiple independent genomic profiling efforts have recently identified clinically and molecularly distinct subgroups of ependymoma arising from all three anatomic compartments of the central nervous system (supratentorial brain, posterior fossa, and spinal cord). These advances motivated a consensus meeting to discuss: (1) the utility of current histologic grading criteria, (2) the integration of molecular-based stratification schemes in future clinical trials for patients with ependymoma and (3) current therapy in the context of molecular subgroups. Discussion at the meeting generated a series of consensus statements and recommendations from the attendees, which comment on the prognostic evaluation and treatment decisions of patients with intracranial ependymoma (WHO Grade II/III) based on the knowledge of its molecular subgroups. The major consensus among attendees was reached that treatment decisions for ependymoma (outside of clinical trials) should not be based on grading (II vs III). Supratentorial and posterior fossa ependymomas are distinct diseases, although the impact on therapy is still evolving. Molecular subgrouping should be part of all clinical trials henceforth.
DOI: 10.1007/s00401-016-1643-0
PubMed: 27858204
Affiliations:
- Allemagne, Australie, Canada, France, Italie, Japon, Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, Auvergne-Rhône-Alpes, Bade-Wurtemberg, Colorado, District de Columbia, District de Karlsruhe, Floride, Hambourg, Latium, Lombardie, Maryland, Nottinghamshire, Ohio, Ontario, Rhône-Alpes, Région de Kantō, Tennessee, Washington (État)
- Cambridge, Hambourg, Heidelberg, Lyon, Milan, Nottingham, Rome, Tokyo, Toronto
- Université de Cambridge, Université de Nottingham, Université de Toronto
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Grundy</name><affiliation wicri:level="4"><nlm:affiliation>Children's Brain Tumour Research Centre, The Medical School, University of Nottingham, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Children's Brain Tumour Research Centre, The Medical School, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Foreman, Nicholas K" sort="Foreman, Nicholas K" uniqKey="Foreman N" first="Nicholas K" last="Foreman">Nicholas K. Foreman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Colorado Denver, Aurora, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Colorado Denver, Aurora, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Gajjar, Amar" sort="Gajjar, Amar" uniqKey="Gajjar A" first="Amar" last="Gajjar">Amar Gajjar</name><affiliation wicri:level="2"><nlm:affiliation>Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, St Jude Children's Research Hospital, Memphis, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Korshunov, Andrey" sort="Korshunov, Andrey" uniqKey="Korshunov A" first="Andrey" last="Korshunov">Andrey Korshunov</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neuropathology, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuropathology, University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Finlay, Jonathan" sort="Finlay, Jonathan" uniqKey="Finlay J" first="Jonathan" last="Finlay">Jonathan Finlay</name><affiliation wicri:level="2"><nlm:affiliation>Nationwide Children's Hospital and the Ohio State University, Columbus, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Nationwide Children's Hospital and the Ohio State University, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Gilbertson, Richard J" sort="Gilbertson, Richard J" uniqKey="Gilbertson R" first="Richard J" last="Gilbertson">Richard J. Gilbertson</name><affiliation wicri:level="4"><nlm:affiliation>Li Ka Shing Centre, CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Li Ka Shing Centre, CRUK Cambridge Institute, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Ellison, David W" sort="Ellison, David W" uniqKey="Ellison D" first="David W" last="Ellison">David W. Ellison</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, St Jude Children's Research Hospital, Memphis, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Aldape, Kenneth D" sort="Aldape, Kenneth D" uniqKey="Aldape K" first="Kenneth D" last="Aldape">Kenneth D. Aldape</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Merchant, Thomas E" sort="Merchant, Thomas E" uniqKey="Merchant T" first="Thomas E" last="Merchant">Thomas E. Merchant</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiological Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiological Sciences, St Jude Children's Research Hospital, Memphis, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Bouffet, Eric" sort="Bouffet, Eric" uniqKey="Bouffet E" first="Eric" last="Bouffet">Eric Bouffet</name><affiliation wicri:level="1"><nlm:affiliation>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M" last="Pfister">Stefan M. Pfister</name><affiliation wicri:level="3"><nlm:affiliation>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. s.pfister@dkfz.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Taylor, Michael D" sort="Taylor, Michael D" uniqKey="Taylor M" first="Michael D" last="Taylor">Michael D. Taylor</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada. mdtaylor@sickkids.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27858204</idno><idno type="pmid">27858204</idno><idno type="doi">10.1007/s00401-016-1643-0</idno><idno type="wicri:Area/PubMed/Corpus">001256</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001256</idno><idno type="wicri:Area/PubMed/Curation">001245</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001245</idno><idno type="wicri:Area/PubMed/Checkpoint">001245</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001245</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants.</title><author><name sortKey="Pajtler, Kristian W" sort="Pajtler, Kristian W" uniqKey="Pajtler K" first="Kristian W" last="Pajtler">Kristian W. Pajtler</name><affiliation wicri:level="3"><nlm:affiliation>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Mack, Stephen C" sort="Mack, Stephen C" uniqKey="Mack S" first="Stephen C" last="Mack">Stephen C. Mack</name><affiliation wicri:level="2"><nlm:affiliation>Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Ramaswamy, Vijay" sort="Ramaswamy, Vijay" uniqKey="Ramaswamy V" first="Vijay" last="Ramaswamy">Vijay Ramaswamy</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Christian A" sort="Smith, Christian A" uniqKey="Smith C" first="Christian A" last="Smith">Christian A. Smith</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Witt, Hendrik" sort="Witt, Hendrik" uniqKey="Witt H" first="Hendrik" last="Witt">Hendrik Witt</name><affiliation wicri:level="3"><nlm:affiliation>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Smith, Amy" sort="Smith, Amy" uniqKey="Smith A" first="Amy" last="Smith">Amy Smith</name><affiliation wicri:level="2"><nlm:affiliation>Arnold Palmer Hospital, Orlando, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Arnold Palmer Hospital, Orlando, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Hansford, Jordan R" sort="Hansford, Jordan R" uniqKey="Hansford J" first="Jordan R" last="Hansford">Jordan R. Hansford</name><affiliation wicri:level="1"><nlm:affiliation>Royal Children's Hospital, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Children's Hospital, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Von Hoff, Katja" sort="Von Hoff, Katja" uniqKey="Von Hoff K" first="Katja" last="Von Hoff">Katja Von Hoff</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Wright, Karen D" sort="Wright, Karen D" uniqKey="Wright K" first="Karen D" last="Wright">Karen D. Wright</name><affiliation wicri:level="2"><nlm:affiliation>Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, St Jude Children's Research Hospital, Memphis, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Hwang, Eugene" sort="Hwang, Eugene" uniqKey="Hwang E" first="Eugene" last="Hwang">Eugene Hwang</name><affiliation wicri:level="2"><nlm:affiliation>Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Frappaz, Didier" sort="Frappaz, Didier" uniqKey="Frappaz D" first="Didier" last="Frappaz">Didier Frappaz</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Neuro-Oncology Centre Léon Bérard, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pediatric Neuro-Oncology Centre Léon Bérard, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Kanemura, Yonehiro" sort="Kanemura, Yonehiro" uniqKey="Kanemura Y" first="Yonehiro" last="Kanemura">Yonehiro Kanemura</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery and Institute for Clinical Research, Osaka National Hospital, Osaka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurosurgery and Institute for Clinical Research, Osaka National Hospital, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Massimino, Maura" sort="Massimino, Maura" uniqKey="Massimino M" first="Maura" last="Massimino">Maura Massimino</name><affiliation wicri:level="3"><nlm:affiliation>Fondazione IRCCS-Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Fondazione IRCCS-Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Faure Conter, Cecile" sort="Faure Conter, Cecile" uniqKey="Faure Conter C" first="Cécile" last="Faure-Conter">Cécile Faure-Conter</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Neuro-Oncology Centre Léon Bérard, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pediatric Neuro-Oncology Centre Léon Bérard, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Modena, Piergiorgio" sort="Modena, Piergiorgio" uniqKey="Modena P" first="Piergiorgio" last="Modena">Piergiorgio Modena</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Genetics, Pathology Unit, S. Anna General Hospital, Como, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Genetics, Pathology Unit, S. Anna General Hospital, Como</wicri:regionArea><wicri:noRegion>Como</wicri:noRegion></affiliation></author><author><name sortKey="Tabori, Uri" sort="Tabori, Uri" uniqKey="Tabori U" first="Uri" last="Tabori">Uri Tabori</name><affiliation wicri:level="1"><nlm:affiliation>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Warren, Katherine E" sort="Warren, Katherine E" uniqKey="Warren K" first="Katherine E" last="Warren">Katherine E. Warren</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Institute, National Institute of Health, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Institute, National Institute of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Holland, Eric C" sort="Holland, Eric C" uniqKey="Holland E" first="Eric C" last="Holland">Eric C. Holland</name><affiliation wicri:level="2"><nlm:affiliation>Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Ichimura, Koichi" sort="Ichimura, Koichi" uniqKey="Ichimura K" first="Koichi" last="Ichimura">Koichi Ichimura</name><affiliation wicri:level="3"><nlm:affiliation>Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Giangaspero, Felice" sort="Giangaspero, Felice" uniqKey="Giangaspero F" first="Felice" last="Giangaspero">Felice Giangaspero</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Castel, David" sort="Castel, David" uniqKey="Castel D" first="David" last="Castel">David Castel</name><affiliation wicri:level="1"><nlm:affiliation>Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Von Deimling, Andreas" sort="Von Deimling, Andreas" uniqKey="Von Deimling A" first="Andreas" last="Von Deimling">Andreas Von Deimling</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neuropathology, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuropathology, University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kool, Marcel" sort="Kool, Marcel" uniqKey="Kool M" first="Marcel" last="Kool">Marcel Kool</name><affiliation wicri:level="3"><nlm:affiliation>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Dirks, Peter B" sort="Dirks, Peter B" uniqKey="Dirks P" first="Peter B" last="Dirks">Peter B. Dirks</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Grundy, Richard G" sort="Grundy, Richard G" uniqKey="Grundy R" first="Richard G" last="Grundy">Richard G. Grundy</name><affiliation wicri:level="4"><nlm:affiliation>Children's Brain Tumour Research Centre, The Medical School, University of Nottingham, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Children's Brain Tumour Research Centre, The Medical School, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Foreman, Nicholas K" sort="Foreman, Nicholas K" uniqKey="Foreman N" first="Nicholas K" last="Foreman">Nicholas K. Foreman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Colorado Denver, Aurora, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Colorado Denver, Aurora, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Gajjar, Amar" sort="Gajjar, Amar" uniqKey="Gajjar A" first="Amar" last="Gajjar">Amar Gajjar</name><affiliation wicri:level="2"><nlm:affiliation>Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, St Jude Children's Research Hospital, Memphis, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Korshunov, Andrey" sort="Korshunov, Andrey" uniqKey="Korshunov A" first="Andrey" last="Korshunov">Andrey Korshunov</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neuropathology, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuropathology, University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Finlay, Jonathan" sort="Finlay, Jonathan" uniqKey="Finlay J" first="Jonathan" last="Finlay">Jonathan Finlay</name><affiliation wicri:level="2"><nlm:affiliation>Nationwide Children's Hospital and the Ohio State University, Columbus, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Nationwide Children's Hospital and the Ohio State University, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Gilbertson, Richard J" sort="Gilbertson, Richard J" uniqKey="Gilbertson R" first="Richard J" last="Gilbertson">Richard J. Gilbertson</name><affiliation wicri:level="4"><nlm:affiliation>Li Ka Shing Centre, CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Li Ka Shing Centre, CRUK Cambridge Institute, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Ellison, David W" sort="Ellison, David W" uniqKey="Ellison D" first="David W" last="Ellison">David W. Ellison</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, St Jude Children's Research Hospital, Memphis, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Aldape, Kenneth D" sort="Aldape, Kenneth D" uniqKey="Aldape K" first="Kenneth D" last="Aldape">Kenneth D. Aldape</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Merchant, Thomas E" sort="Merchant, Thomas E" uniqKey="Merchant T" first="Thomas E" last="Merchant">Thomas E. Merchant</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiological Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiological Sciences, St Jude Children's Research Hospital, Memphis, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Bouffet, Eric" sort="Bouffet, Eric" uniqKey="Bouffet E" first="Eric" last="Bouffet">Eric Bouffet</name><affiliation wicri:level="1"><nlm:affiliation>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M" last="Pfister">Stefan M. Pfister</name><affiliation wicri:level="3"><nlm:affiliation>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. s.pfister@dkfz.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Taylor, Michael D" sort="Taylor, Michael D" uniqKey="Taylor M" first="Michael D" last="Taylor">Michael D. Taylor</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada. mdtaylor@sickkids.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author></analytic><series><title level="j">Acta neuropathologica</title><idno type="eISSN">1432-0533</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain Neoplasms (genetics)</term><term>Brain Neoplasms (metabolism)</term><term>Brain Neoplasms (pathology)</term><term>Brain Neoplasms (therapy)</term><term>Consensus</term><term>Disease Management</term><term>Ependymoma (genetics)</term><term>Ependymoma (metabolism)</term><term>Ependymoma (pathology)</term><term>Ependymoma (therapy)</term><term>Humans</term><term>Neoplasm Staging</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Consensus</term><term>Humains</term><term>Prise en charge de la maladie</term><term>Stade de la tumeur</term><term>Tumeurs du cerveau ()</term><term>Tumeurs du cerveau (anatomopathologie)</term><term>Tumeurs du cerveau (génétique)</term><term>Tumeurs du cerveau (métabolisme)</term><term>Épendymome ()</term><term>Épendymome (anatomopathologie)</term><term>Épendymome (génétique)</term><term>Épendymome (métabolisme)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du cerveau</term><term>Épendymome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Brain Neoplasms</term><term>Ependymoma</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tumeurs du cerveau</term><term>Épendymome</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain Neoplasms</term><term>Ependymoma</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Tumeurs du cerveau</term><term>Épendymome</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain Neoplasms</term><term>Ependymoma</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Brain Neoplasms</term><term>Ependymoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Consensus</term><term>Disease Management</term><term>Humans</term><term>Neoplasm Staging</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Consensus</term><term>Humains</term><term>Prise en charge de la maladie</term><term>Stade de la tumeur</term><term>Tumeurs du cerveau</term><term>Épendymome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multiple independent genomic profiling efforts have recently identified clinically and molecularly distinct subgroups of ependymoma arising from all three anatomic compartments of the central nervous system (supratentorial brain, posterior fossa, and spinal cord). These advances motivated a consensus meeting to discuss: (1) the utility of current histologic grading criteria, (2) the integration of molecular-based stratification schemes in future clinical trials for patients with ependymoma and (3) current therapy in the context of molecular subgroups. Discussion at the meeting generated a series of consensus statements and recommendations from the attendees, which comment on the prognostic evaluation and treatment decisions of patients with intracranial ependymoma (WHO Grade II/III) based on the knowledge of its molecular subgroups. The major consensus among attendees was reached that treatment decisions for ependymoma (outside of clinical trials) should not be based on grading (II vs III). Supratentorial and posterior fossa ependymomas are distinct diseases, although the impact on therapy is still evolving. Molecular subgrouping should be part of all clinical trials henceforth.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27858204</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>18</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>22</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-0533</ISSN><JournalIssue CitedMedium="Internet"><Volume>133</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Acta neuropathologica</Title><ISOAbbreviation>Acta Neuropathol.</ISOAbbreviation></Journal><ArticleTitle>The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants.</ArticleTitle><Pagination><MedlinePgn>5-12</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00401-016-1643-0</ELocationID><Abstract><AbstractText>Multiple independent genomic profiling efforts have recently identified clinically and molecularly distinct subgroups of ependymoma arising from all three anatomic compartments of the central nervous system (supratentorial brain, posterior fossa, and spinal cord). These advances motivated a consensus meeting to discuss: (1) the utility of current histologic grading criteria, (2) the integration of molecular-based stratification schemes in future clinical trials for patients with ependymoma and (3) current therapy in the context of molecular subgroups. Discussion at the meeting generated a series of consensus statements and recommendations from the attendees, which comment on the prognostic evaluation and treatment decisions of patients with intracranial ependymoma (WHO Grade II/III) based on the knowledge of its molecular subgroups. The major consensus among attendees was reached that treatment decisions for ependymoma (outside of clinical trials) should not be based on grading (II vs III). Supratentorial and posterior fossa ependymomas are distinct diseases, although the impact on therapy is still evolving. Molecular subgrouping should be part of all clinical trials henceforth.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pajtler</LastName><ForeName>Kristian W</ForeName><Initials>KW</Initials><AffiliationInfo><Affiliation>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Cancer Consortium (DKTK), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mack</LastName><ForeName>Stephen C</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramaswamy</LastName><ForeName>Vijay</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Christian A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Witt</LastName><ForeName>Hendrik</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Cancer Consortium (DKTK), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Amy</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Arnold Palmer Hospital, Orlando, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hansford</LastName><ForeName>Jordan R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Royal Children's Hospital, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>von Hoff</LastName><ForeName>Katja</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wright</LastName><ForeName>Karen D</ForeName><Initials>KD</Initials><AffiliationInfo><Affiliation>Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hwang</LastName><ForeName>Eugene</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frappaz</LastName><ForeName>Didier</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Pediatric Neuro-Oncology Centre Léon Bérard, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kanemura</LastName><ForeName>Yonehiro</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery and Institute for Clinical Research, Osaka National Hospital, Osaka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Massimino</LastName><ForeName>Maura</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Fondazione IRCCS-Istituto Nazionale dei Tumori, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Faure-Conter</LastName><ForeName>Cécile</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Pediatric Neuro-Oncology Centre Léon Bérard, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Modena</LastName><ForeName>Piergiorgio</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Laboratory of Genetics, Pathology Unit, S. Anna General Hospital, Como, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tabori</LastName><ForeName>Uri</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Warren</LastName><ForeName>Katherine E</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>National Cancer Institute, National Institute of Health, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holland</LastName><ForeName>Eric C</ForeName><Initials>EC</Initials><AffiliationInfo><Affiliation>Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ichimura</LastName><ForeName>Koichi</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giangaspero</LastName><ForeName>Felice</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castel</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UMR8203 "Vectorologie and Thérapeutiques Anticancéreuses", CNRS, Gustave Roussy, Univ. Paris-Sud, Université Paris-Saclay, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>von Deimling</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neuropathology, University of Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kool</LastName><ForeName>Marcel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Cancer Consortium (DKTK), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dirks</LastName><ForeName>Peter B</ForeName><Initials>PB</Initials><AffiliationInfo><Affiliation>Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grundy</LastName><ForeName>Richard G</ForeName><Initials>RG</Initials><AffiliationInfo><Affiliation>Children's Brain Tumour Research Centre, The Medical School, University of Nottingham, Nottingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foreman</LastName><ForeName>Nicholas K</ForeName><Initials>NK</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, University of Colorado Denver, Aurora, CO, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gajjar</LastName><ForeName>Amar</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Korshunov</LastName><ForeName>Andrey</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neuropathology, University of Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Finlay</LastName><ForeName>Jonathan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Nationwide Children's Hospital and the Ohio State University, Columbus, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gilbertson</LastName><ForeName>Richard J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Li Ka Shing Centre, CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ellison</LastName><ForeName>David W</ForeName><Initials>DW</Initials><AffiliationInfo><Affiliation>Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aldape</LastName><ForeName>Kenneth D</ForeName><Initials>KD</Initials><AffiliationInfo><Affiliation>Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merchant</LastName><ForeName>Thomas E</ForeName><Initials>TE</Initials><AffiliationInfo><Affiliation>Department of Radiological Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouffet</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pfister</LastName><ForeName>Stefan M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. s.pfister@dkfz.de.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Heidelberg, Germany. s.pfister@dkfz.de.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Cancer Consortium (DKTK), Heidelberg, Germany. s.pfister@dkfz.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>Michael D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Division of Neurosurgery, Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada. 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RefType="Cites"><RefSource>J Negat Results Biomed. 2011 May 31;10:7</RefSource><PMID Version="1">21627842</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001932" MajorTopicYN="N">Brain Neoplasms</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032921" MajorTopicYN="N">Consensus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019468" MajorTopicYN="N">Disease Management</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004806" MajorTopicYN="N">Ependymoma</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009367" MajorTopicYN="N">Neoplasm Staging</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Ependymoma</Keyword><Keyword MajorTopicYN="N">Posterior fossa</Keyword><Keyword MajorTopicYN="N">RELA</Keyword><Keyword MajorTopicYN="N">Subgroups</Keyword><Keyword MajorTopicYN="N">Treatment</Keyword><Keyword MajorTopicYN="N">Trial</Keyword><Keyword MajorTopicYN="N">YAP1</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>11</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>11</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27858204</ArticleId><ArticleId IdType="doi">10.1007/s00401-016-1643-0</ArticleId><ArticleId IdType="pii">10.1007/s00401-016-1643-0</ArticleId><ArticleId IdType="pmc">PMC5209402</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>France</li><li>Italie</li><li>Japon</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Colorado</li><li>District de Columbia</li><li>District de Karlsruhe</li><li>Floride</li><li>Hambourg</li><li>Latium</li><li>Lombardie</li><li>Maryland</li><li>Nottinghamshire</li><li>Ohio</li><li>Ontario</li><li>Rhône-Alpes</li><li>Région de Kantō</li><li>Tennessee</li><li>Washington (État)</li></region><settlement><li>Cambridge</li><li>Hambourg</li><li>Heidelberg</li><li>Lyon</li><li>Milan</li><li>Nottingham</li><li>Rome</li><li>Tokyo</li><li>Toronto</li></settlement><orgName><li>Université de Cambridge</li><li>Université de Nottingham</li><li>Université de Toronto</li></orgName></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Pajtler, Kristian W" sort="Pajtler, Kristian W" uniqKey="Pajtler K" first="Kristian W" last="Pajtler">Kristian W. Pajtler</name></region><name sortKey="Kool, Marcel" sort="Kool, Marcel" uniqKey="Kool M" first="Marcel" last="Kool">Marcel Kool</name><name sortKey="Korshunov, Andrey" sort="Korshunov, Andrey" uniqKey="Korshunov A" first="Andrey" last="Korshunov">Andrey Korshunov</name><name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M" last="Pfister">Stefan M. Pfister</name><name sortKey="Von Deimling, Andreas" sort="Von Deimling, Andreas" uniqKey="Von Deimling A" first="Andreas" last="Von Deimling">Andreas Von Deimling</name><name sortKey="Von Hoff, Katja" sort="Von Hoff, Katja" uniqKey="Von Hoff K" first="Katja" last="Von Hoff">Katja Von Hoff</name><name sortKey="Witt, Hendrik" sort="Witt, Hendrik" uniqKey="Witt H" first="Hendrik" last="Witt">Hendrik Witt</name></country><country name="États-Unis"><region name="Ohio"><name sortKey="Mack, Stephen C" sort="Mack, Stephen C" uniqKey="Mack S" first="Stephen C" last="Mack">Stephen C. Mack</name></region><name sortKey="Ellison, David W" sort="Ellison, David W" uniqKey="Ellison D" first="David W" last="Ellison">David W. Ellison</name><name sortKey="Finlay, Jonathan" sort="Finlay, Jonathan" uniqKey="Finlay J" first="Jonathan" last="Finlay">Jonathan Finlay</name><name sortKey="Foreman, Nicholas K" sort="Foreman, Nicholas K" uniqKey="Foreman N" first="Nicholas K" last="Foreman">Nicholas K. Foreman</name><name sortKey="Gajjar, Amar" sort="Gajjar, Amar" uniqKey="Gajjar A" first="Amar" last="Gajjar">Amar Gajjar</name><name sortKey="Holland, Eric C" sort="Holland, Eric C" uniqKey="Holland E" first="Eric C" last="Holland">Eric C. Holland</name><name sortKey="Hwang, Eugene" sort="Hwang, Eugene" uniqKey="Hwang E" first="Eugene" last="Hwang">Eugene Hwang</name><name sortKey="Merchant, Thomas E" sort="Merchant, Thomas E" uniqKey="Merchant T" first="Thomas E" last="Merchant">Thomas E. Merchant</name><name sortKey="Smith, Amy" sort="Smith, Amy" uniqKey="Smith A" first="Amy" last="Smith">Amy Smith</name><name sortKey="Warren, Katherine E" sort="Warren, Katherine E" uniqKey="Warren K" first="Katherine E" last="Warren">Katherine E. Warren</name><name sortKey="Wright, Karen D" sort="Wright, Karen D" uniqKey="Wright K" first="Karen D" last="Wright">Karen D. Wright</name></country><country name="Canada"><noRegion><name sortKey="Ramaswamy, Vijay" sort="Ramaswamy, Vijay" uniqKey="Ramaswamy V" first="Vijay" last="Ramaswamy">Vijay Ramaswamy</name></noRegion><name sortKey="Aldape, Kenneth D" sort="Aldape, Kenneth D" uniqKey="Aldape K" first="Kenneth D" last="Aldape">Kenneth D. Aldape</name><name sortKey="Bouffet, Eric" sort="Bouffet, Eric" uniqKey="Bouffet E" first="Eric" last="Bouffet">Eric Bouffet</name><name sortKey="Dirks, Peter B" sort="Dirks, Peter B" uniqKey="Dirks P" first="Peter B" last="Dirks">Peter B. Dirks</name><name sortKey="Smith, Christian A" sort="Smith, Christian A" uniqKey="Smith C" first="Christian A" last="Smith">Christian A. Smith</name><name sortKey="Tabori, Uri" sort="Tabori, Uri" uniqKey="Tabori U" first="Uri" last="Tabori">Uri Tabori</name><name sortKey="Taylor, Michael D" sort="Taylor, Michael D" uniqKey="Taylor M" first="Michael D" last="Taylor">Michael D. Taylor</name></country><country name="Australie"><noRegion><name sortKey="Hansford, Jordan R" sort="Hansford, Jordan R" uniqKey="Hansford J" first="Jordan R" last="Hansford">Jordan R. Hansford</name></noRegion></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Frappaz, Didier" sort="Frappaz, Didier" uniqKey="Frappaz D" first="Didier" last="Frappaz">Didier Frappaz</name></region><name sortKey="Castel, David" sort="Castel, David" uniqKey="Castel D" first="David" last="Castel">David Castel</name><name sortKey="Faure Conter, Cecile" sort="Faure Conter, Cecile" uniqKey="Faure Conter C" first="Cécile" last="Faure-Conter">Cécile Faure-Conter</name></country><country name="Japon"><noRegion><name sortKey="Kanemura, Yonehiro" sort="Kanemura, Yonehiro" uniqKey="Kanemura Y" first="Yonehiro" last="Kanemura">Yonehiro Kanemura</name></noRegion><name sortKey="Ichimura, Koichi" sort="Ichimura, Koichi" uniqKey="Ichimura K" first="Koichi" last="Ichimura">Koichi Ichimura</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Massimino, Maura" sort="Massimino, Maura" uniqKey="Massimino M" first="Maura" last="Massimino">Maura Massimino</name></region><name sortKey="Giangaspero, Felice" sort="Giangaspero, Felice" uniqKey="Giangaspero F" first="Felice" last="Giangaspero">Felice Giangaspero</name><name sortKey="Modena, Piergiorgio" sort="Modena, Piergiorgio" uniqKey="Modena P" first="Piergiorgio" last="Modena">Piergiorgio Modena</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Grundy, Richard G" sort="Grundy, Richard G" uniqKey="Grundy R" first="Richard G" last="Grundy">Richard G. Grundy</name></region><name sortKey="Gilbertson, Richard J" sort="Gilbertson, Richard J" uniqKey="Gilbertson R" first="Richard J" last="Gilbertson">Richard J. Gilbertson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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